Martinsville and Henry County lie in a strategic position in the Mid-Atlantic region halfway between the Roanoke Valley of Virginia and the Piedmont Triad of North Carolina. Four-lane U.S. highways 220 and 58 intersect in Martinsville. U.S. 220 connects the Roanoke Valley and the Piedmont Triad. Highway 58 runs from the Atlantic Ocean at Virginia Beach to Tennessee, along Virginia's Southside.

The Piedmont Triad International Airport, located 45 minutes to the south in Greensboro, NC has over 100 daily departures, including service from USAirways, United, Delta, Continental and American Airlines.

Roanoke Regional Airport, 50 minutes to the north, has approximately 50 daily departures, including jet service from USAirways and United Express and regional service from Delta, American and Northwest Airlines. UPS operates a regional hub adjacent to the airport.

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